Season five of Murdoch Mysteries opens in unfamiliar territory, as Detective William Murdoch (Yannick Bisson) leaves Toronto to try his luck while the Klondike Gold Rush in the Yukon winds down. Suspended for interfering in an investigation, on the run for surreptitiously freeing a murderer to make amends, and nursing a broken heart after Dr. Ogden's marriage to another man, he tries to escape his past, and his passion for detective work. Back in the city, newly promoted Chief Constable Giles (Nigel Bennett) makes it clear to Inspector Thomas Brackenreid (Thomas Craig), that he'll be keeping a very close eye on police matters. Meanwhile, Murdoch's beloved former associate, Dr. Julia Ogden (Hélène Joy), is now working alongside Acting Detective George Crabtree (Jonny Harris) and Dr. Emily Grace (Georgina Reilly), a feisty young protégé. In the remote north, Murdoch is pleased to discover that his fledgling prospecting career may garner great success, a small comfort after Julia's marriage to another man. But as he tries to rebuild his life, he finds himself drawn into the case of Mrs. Elizabeth Bryant (Jill Halfpenny), an innkeeper charged with murder. The plot thickens when writer Jack London (Aaron Ashmore) lends his insights, and Murdoch soon realizes that while he had hoped to leave his shattered heart and tattered career back in Toronto, his days as a detective are not behind him.

浪漫、竞争以及一个极端的秘密。在一次前往遥远岛屿的露营中，黑暗的秘密将一生难求的冒险变为了扭曲的噩梦。

故事讲述一个年轻的男难民被带至一个破旧老屋、交由一对母女照顾。小伙子爱上了女儿，还感觉她受到了恶魔的控制，然而事实的真相却出人意料。

多年来，杰西卡都在为了家人牺牲自ccc。为了父母和弟弟，她放弃了自己的音乐梦；现在，为了弟弟的梦想，她放弃了去洛杉矶见昔日好友的机会。一次偶然，她替爸爸去恩典会教堂修水管，忍不住弹起了琴。钱伯斯牧师被她的音乐吸引了，告诉她教堂面临危机，要举办一百周年庆典来挽回教堂的“生命”，准备唱诗赛，但唱诗班指导走了，希望她可以来指导演唱，她答应了无回报的在唱诗班指导，但遭到了格洛丽亚的怀疑。

三个小混混无缘无故杀死一条14岁的名叫red的狗，这条狗是一位曾经参与过朝鲜战争的兽医最好的朋友，处于半退隐状态的他决意奋起反击讨回正义，无论使用合法或非法的手段……

凯拉·伍兹（Elisha Cuthbert饰）的女儿神秘地消失在他们乡下新房子的地窖里，然而凯拉很快发现，有一个古老而强大的恶魔控制着他们的家，她将不得不面对或冒着永远失去家人灵魂的风险。与卡斯伯特一起最后与宇宙中最古老的邪恶作斗争，否则将永远失去家人的灵魂。

十三年前在一个繁忙的西海岸码头，美丽的金发女理劳拉发现她可爱的三岁女儿失踪了。在这几年以来，劳拉遭受了很多内疚。多年后，劳拉·帕丁顿与丈夫离婚，她想要重新开始她的生活，多年以后，她成为一名有名的律师，并找到一个新的合作伙伴：雅各布，他也失去了一个孩子， 可能失踪的孩子寻找工作使劳拉与青少年雅各布更深接触，起初，当劳拉遇见雅各布的时候，他似乎是完美的人物，雅各布告诉劳拉，她必须从女儿的失踪痛苦的生活里走出来重新开始。

一名十几岁的女孩接受了她诊断的晚期少年巴登病。

在珍妮（阿曼达·贝尼斯 Amanda Bynes 饰）的眼中，歌星杰森（克里斯·卡马克 Chris Carmack 饰）就是她的白马王子，对于苦苦追求她的瑞恩（乔纳森·本内特 Jonathan Bennett 饰），珍妮则选择视而不见。一次意外中，珍妮和杰森遭遇了海难双双漂流到了一座小岛上，不敢相信生命中竟然会有如此好事的珍妮很快就发现，这座岛并非孤岛，而是一处海滨度假村。　　为了制造和偶像独处的机会，珍妮对杰森撒了谎，而维系谎言不被拆穿的任务则落到了瑞恩的头上。阿莱克斯（杰米·林恩·迪斯卡拉 Jamie-Lynn DiScala 饰）的到来让珍妮的心里敲响了警钟，因为两人一直都是情敌关系，而此时的瑞恩则因为被珍妮拒绝而陷入了沮丧的情绪中无法自拔。暴风雨来袭，小岛成为了海上的一叶扁舟，谁能够拯救身陷险境的珍妮呢？

After a stray cat adopts Zachary, he meets Marliee and realizes the single life is not as fulfilling as he thought it was.　　帅哥救了一只猫, 猫帮他找了个女盆友的故事