影片改编自苏珊·斯卡夫·梅瑞尔小说，背景设置在上世纪60年代，讲述了一对年轻夫妇(勒曼、杨饰)搬去与美国哥特惊悚小说家雪莉·杰克逊(莫斯饰)及其丈夫(斯图巴饰)同住，他们因此卷入一场心理惊悚事件，而这也为杰克逊的下一部小说提供了素材。

Creature of habit, Jon Smith, spends his days mindlessly working as a barista in New York City. When night falls, this seeming everyman savagely kills filthy women as his social outlet. A chance encounter with Delia, a young prostitute searching for an escape from her troubled past, forces Jon to confront the most terrifying thing he has ever faced in all his dark affairs - himself. All God's Creatures examines the true nature of what it means to be a monster and reveals that love is not only for a chosen few, but for all God's creatures.